The autumn of November 3, 2017 is the best time to hold group events and strengthen the cohesion of the company. Guangzhou Jianlun Biotechnology Co., Ltd. upholds the concepts and attitudes of solidarity, fraternity, mutual aid, dedication, collaboration, and innovation. To improve the physical fitness of employees and strengthen corporate culture, it actively participates in the Games organized by this Science Park.

At 2 o'clock in the afternoon, in the sun, in the song, on the field, the first fun games of Panyu Innovation and Technology Park kicked off! With the high voice of the host, the crowds on the court lined up in neat rows. The team leader stood in the front of the team holding up the signs of each representative team. The participating athletes were eagerly arranged in the ranks and waiting for the start of the sports meeting. Then, the leader of the Science Park and the leader of the Guangzhou Mountaineering Association made a speech and wished the Games a success!

After the opening ceremony, under the leadership of the host, the athletes completed the warm-up exercise. The upcoming game is a rousing game. The company's first competition program is to test the coordination of the body and teamwork thunderbolt. As the whistle sounded, six colleagues carefully waved the balloons on the drums with a concerted pace and rhythm. The two colleagues were waiting for their help and were ready to pick up the flunging balloons. With nervousness and excitement, every colleague is working hard to complete the game. With the sound of the referee's ending, colleagues were relaxed, but due to lack of exercise, our performance on this project was not satisfactory. The company’s leader, Zhan Zhan, encouraged everyone at this time to cheer up morale and achieved better results in the next game.

At three o'clock in the afternoon, the colleagues of Jianlun Biology were engaged in a penalties game. Accompanied by cheers, I saw my colleagues kick one exciting goal after another and the score went up. In the end, Jianlun Bios achieved good results in the top five on this project. During the intermission, Zhan summoned everyone to a brief summary and encouraged everyone to continue their efforts to achieve better performance. Sure enough, in the following tortoise-bitch races and super-shooting sessions, colleagues performed better and better, demonstrating the positive appearance of Jianlun Biocorp. and the corporate culture of solidarity and cooperation.

At five o'clock in the afternoon, as the last athlete crossed the finish line, the game also came to a close. In the next award ceremony, the winning teams and athletes received commendation and prizes. The sports event was over, but the success and spirit gained through the games will continue to circulate, and it will become a shining landscape on the path of Guangzhou Jianlun Biosciences!

努力，我们一直在路上，明天会更好！

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【公司名称】广州健仑生物科技有限公司

【市场部】杨永汉
【】
【腾讯】
【公司地址】广州市清华科技园健新基地番禺石楼镇健启路63号二期2幢101-103室

(metlproteinse,MP)类，如胶原酶IV、基质降解酶、透明质酸酶.恶性肿瘤的发生、发展、侵袭和转移常常伴有细胞外基质 (extrcellulr mtrix,ECM)及其细胞表面受体表达的变化。正常肝细胞没有基膜，也不表达层粘连蛋白(lminin,LN)的特异性整合素族受体αβ；而在肝细胞癌(humn heptocellulr crcinom,HCC)组织中，LN和αβ不仅表达水平升高，呈明显的共分布，而且其高水平表达与肝癌患者的预后呈负相关，提示 HCC细胞可能通过αβ受体接受来自LN的信号，从而对肝癌细胞的侵袭行为起着不可忽视的作用。肝癌的发病过程中往往早期就出现门静脉侵袭、肝内转移以及肝外肺脏和骨组织的转移，肝癌的侵袭、转移和术后复发是影响患者预后的主要因素。基质金属蛋白酶 (mtrix met-lloproteinses,MMPs)对ECM的降解是肿瘤细胞侵袭和转移的关键环节之一，多种恶性肿瘤都伴有MMPs分泌水平和活性的增高。细胞外基质(ECM)是组成间质和上皮血管中基质的不溶性结构成分，主要有胶原蛋白、弹性蛋白、蛋白多糖和糖蛋白等。
(metylproteinse, MP) class, such as collagenase IV, matrix degrading enzyme, hyaluronidase. The occurrence, development, invasion, and metastasis of malignant tumors are often accompanied by expression of extracellular matrix (ECM) and its cell surface receptors. The change. Normal hepatocytes do not have a basement membrane and do not express laminin (LN)-specific integrin receptor αβ; whereas in hepatocellular carcinoma (HCC), LN and αβ not only express higher levels of expression. It is highly co-distribution, and its high-level expression is negatively correlated with the prognosis of patients with liver cancer, suggesting that HCC cells may receive signals from LN through the αβ receptor, and thus play an important role in the invasion behavior of hepatoma cells. In the process of liver cancer, portal vein invasion, intrahepatic metastasis, and extrahepatic lung and bone metastasis often occur early. The invasion, metastasis, and postoperative recurrence of liver cancer are the main factors affecting the prognosis of patients. The degradation of ECM by matrix metalloproteinases (MMPs) is one of the key steps in the invasion and metastasis of tumor cells. Many malignant tumors are accompanied by an increase in the secretion level and activity of MMPs. The extracellular matrix (ECM) is the insoluble structural component that constitutes the matrix in the interstitial and epithelial blood vessels, and is mainly composed of collagen, elastin, proteoglycans and glycoproteins.

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