20q探针

20q探针

 广州健仑生物科技​有限公司 

本司长期供应尼古丁（可替宁）检测试剂盒，其主要品牌包括美国NovaBios、广州健仑、广州创仑等进口产品，国产产品，试剂盒的实验方法是胶体金方法。

我司还有很多荧光原位杂交系列检测试剂盒以及各种FISH基因探针和染色体探针等，。

20q探针

     20q出现缺失见于骨髓增殖性疾病（MPD）/骨髓异常增生综合征（MDS）（4%）/急性粒细胞白血病（AML）（1%）等疾病中；其中20q12微小区域缺失见于MPD和MDS中。-20/20q-的患者预后较好，可用于指导临床进行预后判断和治疗方案的选择，如可采用促进造血、诱导分化和生物反应调节剂等方式进行治疗。

本试剂盒主要用于白血病的20q的检测，里面包括即用型杂交液和DAPI复染剂。

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以下是我司出售的部分FISH产品：

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【公司名称】 广州健仑生物科技有限公司
【】    杨永汉 

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【腾讯 】
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-3室

【企业文化宣传】

Let a lot of old are with nasopharyngeal carcinoma. 40% of the world's nasopharyngeal cancer cases occur in China, especially in Guangdong and other provinces in the Southern China region. Therefore, nasopharyngeal carcinoma is called "Guangdong tumor".

Ma Jun introduced that about 70% of nasopharyngeal carcinoma patients were already in the late part of the local area when they visited the doctor. "Nasopharyngeal carcinoma metastasis is still limited to the neck, and no distant metastasis has occurred. It has not run to the liver, lung and other organs." At present, this type of patients still has 20-30% in the treatment of distant metastasis, "walk on the disease does not return", the main reason for the failure of the treatment. The accuracy of the distant metastasis is only about 57% by the traditional N staging method. Moreover, patients with similar staging often have different survival outcomes after receiving the same treatment. There is lack of effective markers in clinical practice to guide the selection of treatment options for nasopharyngeal carcinoma patients.

In recent years, with the development of molecular biology, many molecular biological indicators have been included in the evaluation system of tumor prognosis. Is there a group of gene expression changes that can predict metastasis risk of nasopharyngeal carcinoma?

To this end, Professor Ma Jun has carried out the research on the largest molecular marker of nasopharyngeal carcinoma in the world. Team doctor Tang Xinran introduced, compared and analyzed of nasopharyngeal carcinoma gene expression level, from tens of thousands of genes initially identified 137 differentially expressed genes, with statistical method from 410 patients screened 13 genes associated with distant metastasis, construction of molecular tags, the patients were divided into high risk group and the low risk group forecast. The results showed that the 5 year distant metastasis rate was 37% in the high risk group and only 9% in the low risk group.

这项研究由美国、加拿大、德国、瑞典等国的研究人员联合展开，他们对现存和已灭绝的象类的１４个基因组进行了测序，其中已灭绝的有美洲乳齿象、古棱齿象、哥伦比亚猛犸象和真猛犸象，现存的有亚洲象、非洲森林象和非洲草原象。

　　这项２６日发表在美国《国家科学院学报》上的研究显示，古棱齿象混合了古非洲象、真猛犸象和非洲森林象的基因。

　　此外，哥伦比亚猛犸象和真猛犸象之间也有杂交现象，尽管两者体型和栖息地不同。研究人员推测，在当时覆盖大陆大部分地区的冰川与北美洲温带地区交汇的地方，真猛犸象与哥伦比亚猛犸象相遇。

　　研究报告作者之一、加拿大麦克马斯特大学进化遗传学家亨德里克·波伊纳说：“基因组数据表明，大象的进化并非以有组织的、线性的方式展开。”

　　在现存的大象中，关于非洲森林象和非洲草原象是否是两种不同的物种，学术界一直存在争议。新研究发现，非洲森林象和非洲草原象不存在杂交的基因证据，尽管两者的栖息地相邻，但它们在过去５０万年中近乎*隔绝繁衍。

　　研究人员表示，未来将继续研究新基因的引入是否有利于大象适应新栖息地和波动变化的气候。

There are many factors in the pathogenesis of nasopharyngeal carcinoma. For many years, clinical and experimental studies have shown that the following factors are closely related to the occurrence of nasopharyngeal carcinoma.
1. genetic factors
(1) familial aggregation of many nasopharyngeal cancer patients have a family history of cancer. Nasopharyngeal carcinoma has a vertical and horizontal familial tendency.
(2) race susceptibility of nasopharyngeal carcinoma mainly in yellow, rare in Caucasians; high incidence of people emigrated (or overseas Chinese), their descendants still have a higher incidence of.
(3) regional concentrated nasopharyngeal carcinoma mainly occurs in five provinces of South China, namely Guangdong, Guangxi, Hunan, Fujian and Jiangxi, accounting for the first place in the head and neck cancer. South East Asian countries are also high - incidence areas.
(4) susceptibility genes in recent years, molecular genetics study found that nasopharyngeal carcinoma cell chromosome changes were 1, 3, 11, 12 and 17 chromosomes in nasopharyngeal carcinoma cells were found in many areas of chromosomal loss of heterozygosity (1P, 9p, 9q, 11q, 13q, 14q and 16q) may there is variation in multiple tumor suppressor genes suggest the occurrence and development of nasopharyngeal carcinoma.
2. virus infection
In 1964, Epstein and Barr first established a lymphoblastoid cell strain that could be passed from the biopsy tissue of African children's lymphoma (Burkitt lymphoma). Herpes virus particles were observed under electron microscope. Because it has different characteristics from other members of the herpes virus family, it is named Epstein-Barr virus, that is, EB virus.
The virus like lymphoblastoid cells can be isolated from the nasopharyngeal carcinoma tissue, and a few of the virus particles are visible under the electron microscope. Immunological and biochemical studies have confirmed that EB virus is closely related to nasopharyngeal carcinoma. The dynamic changes and monitoring of the titer of EB virus antibody can be used as an indicator of clinical diagnosis, prognosis and follow-up monitoring.
In addition to the EB virus, other viruses, such as coronavirus, are also considered to be involved in the development of nasopharyngeal carcinoma.
3. environmental factors
There are reports that the mortality rate of nasopharyngeal cancer in Chinese people migrating abroad has gradually decreased with the genetic algebra.  On the other hand, the white people born in Southeast Asia have increased the risk of nasopharyngeal cancer. It is suggested that environmental factors may play an important role in the pathogenesis of nasopharyngeal carcinoma.
The epidemiological survey found that the infants in the high incidence area of nasopharyngeal carcinoma in Guangdong province have salted fish in the first contact food after weaning. In addition, Guangdong cured and dried fish, also about the incidence of nasopharyngeal carcinoma. Nitrosamine precursors are all nitrite during the pickling process of these foods. When the pH value of the human gastric juice is 1~3, nitrite or nitrate, which is reduced to nitrite by cells, can be used to synthesize nitrosamines with secondary amines in the cells. These substances have a strong carcinogenic effect.
Some trace elements such as nickel, such as nickel, can also induce nasopharyngeal carcinoma.