嗜肺军团菌快速检测试剂（免疫捕获法）

EIKEN嗜肺军团菌快速检测试剂（免疫捕获法）

广州健仑生物科技有限公司

主要用途：用于检测尿样中嗜肺军团菌血清型1抗原，以支持军团菌感染的诊断。

产品规格：20T/盒

存储条件：2-30℃

EIKEN嗜肺军团菌快速检测试剂（免疫捕获法）

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【产品介绍】

EIKEN

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【公司名称】 广州健仑生物科技有限公司
【】    杨永汉 
【】 
【腾讯 】 2042552662
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-3室
【企业文化】

在该项研究中，研究人员*综合利用HDAdV，TALEN和CRISPR三种不同的方法，对镰刀形细胞贫血症患者iPSC中发生突变的血红蛋白基因(HBB)进行靶向矫正。发现这三种基因矫正方法对于HBB基因具有类似的打靶效率。同时，全基因组深度测序结果显示，TALEN和HDAdV在基因矫正过程中zui大限度地保持了病人基因组的完整性，从而提示了这些方法的安全可靠性。
进而，研究人员充分整合TALEN和HDAdV作为基因组靶向修饰工具的*优势，发展出一种新型高效的疾病基因矫正载体HDAdV。HDAdV同时具有TALEN的特异性基因组切割和HDAdV的高导入效率及精确的大片段同源重组效率。同一个HDAdV可有效涵盖HBB基因座上所有可能包含的遗传突变，因此可被广泛应用于包括镰刀形细胞贫血症和地中海贫血症在内的不同种类的血红蛋白疾病的基因修复。实验结果表明，HDAdV介导的基因修复比单独使用TALEN和CPRISPR在效率上约高数十倍，可被应用于不同种类的人类致病基因突变的靶向矫正。
该研究打消了干细胞和再生医学研究领域针对疾病基因靶向修复安全性的忧虑;同时，新型基因矫正载体的问世也将有助于加速干细胞临床转化的步伐。Cell Stem Cell杂志同期发表的题为“What’s Changed with Genome Editing?”的Preview评论说：“这些发现将无疑鼓舞将基因组靶向编辑技术进一步应用于疾病研究和临床治疗”。
该工作得到科技部、基金委及中科院干细胞与再生医学战略先导专项等资助。
在细胞核中DNA缠绕着称之为组蛋白的特殊蛋白质。通常情况下，组蛋白使得DNA紧密包装，阻止了基因表达和DNA复制，后两者是细胞生长和分裂的必要条件。为了让这些至关重要的功能得以执行，需要由一种叫做乙酰辅酶A(acetyl-CoA)的关键分子提供乙酰基，附着到组蛋白上对其进行修饰。这种附着使得DNA松弛,允许DNA复制和基因表达。这一称作为“DNA表观遗传调控”的机制对于正常的功能，以及心脏衰竭或癌症等常见疾病均极为重要。然而直到现在，对于细胞核生成组蛋白乙酰化所需的乙酰辅酶A的机制仍不清楚。

In this study, for the first time, the researchers used three different approaches, HDAdV, TALEN and CRISPR, to target-correct hemoglobin gene (HBB) mutations in iPSC in patients with sickle cell anemia. These three methods of gene correction were found to have similar targeting efficiency to HBB genes. At the same time, genome-wide deep sequencing showed that TALEN and HDAdV kept the integrity of the patient's genome during gene correction, which indicated the safety and reliability of these methods.
Furthermore, the researchers fully integrated the unique advantages of TALEN and HDAdV as genomics-targeted modifiers to develop a new and efficient disease-modifying gene, HDAdV. HDAdV has both TALEN specific genomic cleavage and HDAdV high import efficiency and accurate large fragment homologous recombination efficiency. The same HDAdV effectively covers all possible genetic mutations in the HBB locus and therefore can be widely used for gene repair of different kinds of hemoglobin diseases including sickle cell anemia and thalassemia. The experimental results show that HDAdV-mediated gene repair is about a dozen times more efficient than TALEN and CPRISPR alone and can be used to target different types of human pathogenic mutations.
The study dispelled concerns about the safety of disease-targeted gene repair in stem cell and regenerative medicine research. Meanwhile, the advent of a new gene correction vector will also help accelerate the clinical transformation of stem cells. Preview comments from Cell Stem Cell, titled "What's Changed with Genome Editing?", Said: "These findings will undoubtedly encourage the further application of genome-targeted editing techniques in disease research and clinical treatment."
The work was funded by the Ministry of Science and Technology, the Commission and the CAS Stem Cell and Regenerative Medicine Strategy Pilot Project.
In the nucleus, DNA wraps around special proteins called histones. Typically, histones make DNA tightly packed, preventing gene expression and DNA replication, both of which are necessary for cell growth and division. To enable these crucial functions to be performed, it is necessary to provide an acetyl group from a key molecule called acetyl-CoA, which is attached to the histone to modify it. This attachment relaxes the DNA, allowing DNA replication and gene expression. This mechanism, called "DNA epigenetic regulation," is crucial for normal function and for common diseases such as heart failure or cancer. Until now, however, the mechanism of acetyl-CoA required for acetylation of histones in nucleus formation remained unclear.