军团菌检测试剂盒

EIKEN军团菌检测试剂盒

广州健仑生物科技有限公司

主要用途：用于检测尿样中嗜肺军团菌血清型1抗原，以支持军团菌感染的诊断。

产品规格：20T/盒

存储条件：2-30℃

EIKEN军团菌检测试剂盒

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【产品介绍】

EIKEN

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【公司名称】 广州健仑生物科技有限公司
【】    杨永汉 
【】 
【腾讯 】 2042552662
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-3室
【企业文化】

研究者Peter M. Glazer博士表示，长期以来我们一直知道含氧量低的肿瘤组织和较差的预后直接相关，但是含氧量低的肿瘤中往往也会发生某些特殊基因的沉默，这未必就是一件坏事;如今我们知道了缺氧状态在诱发肿瘤恶化中的分子机制，下一步我们将通过更为深入的研究来解释缺氧条件影响其它肿瘤抑制基因的分子机制。
白血病是一类造血干细胞恶性克隆性疾病，在儿科恶性肿瘤的发病率中居*位，它的死亡率在导致儿童及35岁以下成年人死亡的恶性肿瘤中排*。电离辐射是一个常见的致癌物，对白血病的发生非常关键。然而，其表观学遗传机制依然有很大一部分不为人知。
来自加拿大莱斯布里奇大学的研究团队对小鼠胸腺中电离辐射(IR)引起的 micrornAome变化进行了研究，研究成果发布在6月刊的International Journal of Radiation Oncology*Biology*Physics上。
研究人员通过miRNA表达谱芯片分析(miRNA芯片项目由联川生物承担完成)鉴定小鼠胸腺中应答辐射时差异表达的miRNAs，证实了在小鼠胸腺组织中IR能引起miR-27b差异表达，且呈剂量、时间和性别依赖的方式。在白血病细胞系CCL119和TIB152中，miR-27b表达被明显抑制。有趣的是，ERα在上述两个细胞系中过量表达，并与miR-27b表达呈负相关。
深入研究发现，β-雌二醇/ERα信号可能通过ERK1/2途径，引起急性白血病细胞中miR-27b的表达下调，miR-27b可能通过结合细胞周期蛋白A2抑制细胞增殖，起到肿瘤抑制的作用。
此研究证实了IR能引起miR-27b差异表达，从而对白血病发生造成影响，为其表观学遗传机制提供了新见解，也为白血病的研究与治疗提供了新思路。
美国怀俄明大学分子生物学系的副教授娜奥米·沃德，是zui近发表在美国国家科学院(PNAS)上的论文的资深作者。该研究探讨了简单的细菌细胞如何过渡到更为复杂的细胞，发展出植物，动物和人类。这项研究由美国国家科学基金会(NSF)资助。
Ekaterina Gottshall，分子和细胞生命科学博士计划的研究生，这篇文章的*作者，实验工作的主要贡献者。其他的作者有分子生物学系副教授杰伊·加特林和沃德研究组的副研究员Corrine Seebart。

Dr. Peter M. Glazer, a researcher, said it has long been known that low oxygenated tumor tissues are directly linked to poor prognosis, but the silencing of specific genes often occurs in low oxygenated tumors, Is a bad thing; now we know the molecular mechanism of hypoxia in the induction of tumor progression, the next step we will be more in-depth study to explain the hypoxic conditions affect the molecular mechanisms of other tumor suppressor genes.
Leukemia, a hematopoietic malignant clonal disease of hematopoietic stem cells, ranks first in the incidence of pediatric malignancies and its mortality rate ranks first in malignancies leading to the death of children and adults under 35 years of age. Ionizing radiation is a common carcinogen that is crucial for the development of leukemia. However, a large part of its apparent genetic mechanism remains unknown.
A study team from the University of Lethbridge, Canada, studied the micrornAome changes induced by ionizing radiation (IR) in the mouse thymus, and the findings were published in the June issue of the International Journal of Radiation Oncology * Biology * Physics.
The researchers identified miRNAs that were differentially expressed during radiation response in the mouse thymus by miRNA profiling (miRNA microarray project was performed by UMC) and demonstrated that IR can cause differential expression of miR-27b in mouse thymus and that In a dose, time and gender-dependent manner. In the leukemia cell lines CCL119 and TIB152, miR-27b expression was significantly inhibited. Interestingly, ERα was overexpressed in both cell lines and negatively correlated with miR-27b expression.
In-depth study found that, β-estradiol / ERα signal may be through the ERK1 / 2 pathway, causing the expression of miR-27b in acute leukemia cells downregulation, miR-27b may inhibit cell proliferation by binding to cyclin A2, play a tumor suppressor effect.
This study confirmed that IR can cause the differential expression of miR-27b, which has an impact on the occurrence of leukemia, providing new insights into its apparent genetic mechanism, but also provides a new idea for the study and treatment of leukemia.
Naomi Ward, an associate professor of molecular biology at the University of Wyoming, is a senior author of recent papers published at the National Academy of Science (PNAS). The study explored how simple bacterial cells transition to more complex cells, developing plants, animals and humans. The study was funded by the National Science Foundation (NSF).
Ekaterina Gottshall, a graduate student in the Molecular and Cell Life Sciences Ph.D. program, is the lead author of this article and a major contributor to experimental work. Other authors include Jay Gatlin, associate professor of molecular biology and Corrine Seebart, associate research associate at Ward.