鼠型斑疹伤寒立克次体IgM ELISA试剂盒

鼠型斑疹伤寒立克次体IgM ELISA试剂盒

R. typhi IgG ELISA Kit 

广州健仑生物科技有限公司

主要用途：用于检测人血清中的鼠型斑疹伤寒立克次体IgM抗体

产品规格：96T/盒

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鼠型斑疹伤寒立克次体IgM ELISA试剂盒

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【公司名称】 广州健仑生物科技有限公司
【】    杨永汉 
【】 
【腾讯 】 2042552662
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-3室
【企业文化】

Smerdon和Mao的发现是*记录了修复过程在染色质上是如何发生的细节之一。
DNA修复日常需求
Smerdon说，每个人体细胞都会遭受各种各样的攻击，每天zui多可以创建100,000 个DNA损伤。细胞必须不断的修复这些损伤，以及迅速产生可替代的DNA和蛋白质。
RNA聚合酶就像一个小火车头，不断来回地进行DNA的复制遗传信息。当它达到蛋白质是细胞所需的一个基因时，它就会停止，并解开双链DNA，然后复制一条链，并将这条链发送到机器中生产新的蛋白质。
但是，Smerdon说，当DNA遭到紫外线辐射或有害物质损坏时，它就会形成一个坚不可摧的块状，使得RNA聚合酶停止。就像铁轨上的巨石，毫无生命的肿块阻断了该基因生产所有的蛋白质。除非很快就能够进行修复，否则细胞就会死亡。
在健康的人群中，酶的维修人员与RNA聚合酶一同移动，并立即冲进去切除损伤和消除痕迹。这就是所谓的转录偶联修复，或TCT，四个已知的DNA修复系统之一的一个方面。Smerdon说，在任何修复系统中，甚至只有局部缺陷都有可能导致危及生命的病症。
月球来的孩子
Smerdon的实验室研究了修复缺陷疾病，如着色性干皮病或XP，在1874年*发现作为一个可能的遗传疾病。被称为月球来的孩子，XP患者缺乏切除受损DNA的酶，并对紫外线照射非常敏感，甚至在荧光灯下，皮肤都能够起泡。
他们的皮肤癌发病率比没有异常的人们高出2000倍。他们只有在黑暗中才能够安全。
Smerdon和他的同事还研究科凯恩综合征，一种TCR缺陷疾病，可导致的阳光敏感，神经系统退化和过早老化。
其他的DNA修复缺陷也可导致各种各样的疾病，如白血病，抗原抗体癌和遗传性非息肉性大肠癌(导致西方国家大肠癌的一种常见原因)。

The discovery by Smerdon and Mao was one of the first to document how the repair process took place on the chromatin.
DNA repair daily needs
Smerdon says each human cell suffers from a variety of attacks that create up to 100,000 DNA damage per day. Cells must constantly repair these lesions and rapidly produce alternative DNA and protein.
RNA polymerase is like a small locomotive, DNA replication genetic information back and forth. When it reaches the protein, which is a gene your cell needs, it stops and unlocks double-stranded DNA, then duplicates a strand and sends it to the machine to make new proteins.
However, Smerdon said that when DNA is damaged by UV radiation or harmful substances, it forms an indestructible block that stops RNA polymerase. Like boulders on rails, inanimate lumps block the production of all the proteins in the gene. Unless repaired soon enough, or the cell will die.
In a healthy population, enzyme maintainers move with the RNA polymerase and immediay rush in to remove the lesion and remove traces. This is one aspect of one of the four known DNA repair systems called TCT, or TCT. Smerdon said that even in the case of any repair system, only partial defects can lead to life-threatening conditions.
Children from the moon
Smerdon's lab studied repair of defective diseases such as xeroderma pigmentosum or XP, first discovered in 1874 as a possible genetic disorder. Known as the child from the moon, XP patients lack the enzyme to remove damaged DNA and are very sensitive to UV light, even under fluorescent lighting.
Their skin cancer rates are 2000 times higher than those without abnormalities. They can be safe only in the darkness.
Smerdon and his colleagues also studied Cockney's syndrome, a TCR-deficient disease that can cause extreme sun sensitivity, nervous system degeneration and premature aging.
Other defects in DNA repair can also lead to a variety of diseases such as leukemia, antigen-antibody and hereditary non-polypost colorectal cancers (a common cause of colorectal cancer in Western countries).