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凝固因子C4(Clotting Factor C4)

凝固因子C4(Clotting Factor C4)

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美国Seracare凝固因子C4(Clotting Factor C4) 阳性质控品对照品 需要了解更多Seracare产品可以咨询我们,本产品由广州健仑生物科技有限公司提供

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美国Seracare凝固因子C4(Clotting Factor C4)

广州健仑生物科技有限公司

广州健仑长期供应各种生物原料,主要代理品牌:美国Seracare、西班牙Certest、美国Fuller等等。

主要产品包括各种标准品、阳性对照品、单克隆抗原抗体。

其中常见的有:弓形虫病、西尼罗河病毒、类风湿因子、疟疾、麻疹、莱姆病、百日咳杆菌、大肠杆菌、鼠伤寒沙门氏菌、李斯特菌等阳性对照品。

美国Seracare凝固因子C4(Clotting Factor C4)

我司还提供其它进口或国产试剂盒:登革热、疟疾、流感、A链球菌、合胞病毒、腮病毒、乙脑、寨卡、黄热病、基孔肯雅热、克锥虫病、违禁品滥用、肺炎球菌、军团菌、化妆品检测、食品安全检测等试剂盒以及日本生研细菌分型诊断血清、德国SiFin诊断血清、丹麦SSI诊断血清等产品。

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【Seracare产品介绍】

编号

英文名称

中文名称

JL-FA-01

Amebiasis (AME)

阿米巴病

JL-FA-02

Allergens, Rast scores

过敏原,放射性过敏原吸收实验。指对特定的人群引起免疫反应或者过敏反应的食品中的蛋白质

JL-FA-03

Allergens, Rast scores negative

过敏原,放射性过敏原吸收实验阴性

JL-FA-04

Anti-cyclic citrullinated peptide Antibody (CCP) Arthritis

抗环瓜氨酸肽抗体

JL-FA-05

ASCA Saccharomyces Cerevi

人抗酿酒酵母抗体(ASCA)

JL-FA-06

Aspergillis

麴菌病

JL-FA-07

Beta 2 Glycoprotein

β2糖蛋白

JL-FA-08

Beta 2 Glycoprotein  IgM

β2糖蛋白 IGM

JL-FA-09

Bordela Pertussis

百日咳杆菌

JL-FA-10

Bordela Pertussis IgM

百日咳杆菌 IGM

JL-FA-11

C-ANCA

C-抗中性粒细胞胞浆抗体(ANCA)

JL-FA-12

Cardiolipin

心肌磷脂

JL-FA-13

Cardiolipin IgA

心肌磷脂 IGA

JL-FA-14

Cardiolipin IgG

心肌磷脂 IGG

JL-FA-15

Cardiolipin IgM

心肌磷脂 IGM

JL-FA-16

Cerebral Spinal Fluid

脑脊髓液

JL-FA-17

Chagas

恰加斯病/南美锥虫

JL-FA-18

Chlamydia

衣原体

JL-FA-19

Chlamydia IgA

衣原体IGA

JL-FA-20

Chlamydia IgG

衣原体IGG

JL-FA-21

Chlamydia IgM

衣原体IGM

JL-FA-22

Chlamydia Neg

衣原体阴性

JL-FA-23

Clotting Factor C3

凝固因子C3

JL-FA-24

Clotting Factor C4

凝固因子C4

JL-FA-25

Coccidiodes

球孢菌

JL-FA-26

Cytomegalovirus (CMV) Neg

巨细胞病毒抗体阴性

JL-FA-27

CMV IgG

巨细胞病毒 IGG阳性

JL-FA-28

CMV IgM VCA

巨细胞病毒 IGM 阳性

JL-FA-29

C-Reactive Protein (CRP)

C-反应蛋白质

JL-FA-30

Dengue Fever

登革热

JL-FA-31

Dengue Fever IgM

登革热 IGM

JL-FA-32

DS (Double Stranded) DNA

双链脱氧核糖核酸

JL-FA-33

EBNA (Epstein-Barr nuclear antigen) IgG

EB病毒核抗原 IGG

JL-FA-34

EBNA (Epstein-Barr nuclear antigen) IgM

EB病毒核抗原 IGM

JL-FA-35

Epstein Barr Virus (EBV) Negative Plasma

EB病毒阴性血浆

JL-FA-36

Epstein Barr Virus (EBV) EA IgM

EB病毒早期抗原 IGM

JL-FA-37

Epstein Barr Virus (EBV) VCA IgM

EB病毒壳蛋白  IGM

JL-FA-38

Epstein Barr Virus (EBV) EA IgG

EB病毒早期抗原 IGG

JL-FA-39

EMA (Endomysial Antibodies)

肌内膜

JL-FA-40

Gliadin

麸蛋白,麦醇溶蛋白,麦胶蛋白

JL-FA-41

Gliadin IgG

麦醇溶蛋白  IGG

JL-FA-42

Gliadin IgA

麦醇溶蛋白 IGA

JL-FA-43

Glomerular Basement Membrane (GBMA)

肾小球基底膜病

JL-FA-44

Helicobacter pylori IgA

幽门螺旋杆菌IGA

JL-FA-45

Helicobacter pylori IgG

幽门螺旋杆菌IGG

JL-FA-46

Helicobacter pylori IgM

幽门螺旋杆菌IGM

JL-FA-47

Helicobacter pylori Negative

幽门螺旋杆菌阴性

JL-FA-48

Helicobacter pylori Positive Plasma

幽门螺旋杆菌阴性血浆

JL-FA-49

Hepatitis A Virus (HAV) Pos. Plasma

甲型肝炎病毒阳性血浆

JL-FA-50

Hepatitis A Virus (HAV) IgM

甲型肝炎病毒IGM

JL-FA-51

Hepatitis B Core (HBc) IgG

乙型肝炎病毒核心 IGG

JL-FA-52

Hepatitis B Core (HBc) IgM

乙型肝炎病毒核心 IGM

JL-FA-53

Anti Hbe (Antibody to HBV antigen)

乙肝抗体

JL-FA-54

Hepatitis Delta Virus

丁型肝炎病毒

JL-FA-55

HBeAg (HBV e antigen)

乙肝 E抗原

JL-FA-56

anti-HBs (HBV surface antibody)

乙肝表面抗体

JL-FA-57

Hepatitis B (HBsAg) "Chronic"

乙型肝炎(乙肝表面抗原)“慢性病

JL-FA-58

HBsAg (HBV surface antigen) Serum

乙肝表面抗原血清

JL-FA-59

HBsAg (AD)

乙肝表面抗原(AD)

JL-FA-60

HBsAg (AY)

乙肝表面抗原(AY)

JL-FA-61

HBV Positive Plasma

乙肝阳性血浆

JL-FA-62

HBV DNA Plasma

乙肝DNA血浆

JL-FA-63

HBV DNA Serum

乙肝DNA血清

JL-FA-64

HBV DNA type A

 A型 乙肝DNA

JL-FA-65

HBV DNA type B

 B型 乙肝DNA

JL-FA-66

HBV DNA type C

 C型 乙肝DNA

JL-FA-67

HBV DNA type D

 D型 乙肝DNA

JL-FA-68

HBV DNA type E

 E型 乙肝DNA

JL-FA-69

HBV DNA type F

 F型 乙肝DNA

JL-FA-70

HBV Antibody HCV Antibody Plasma CO-INFECTED

乙肝和丙肝联合感染血浆

JL-FA-71

HCV (Hepatitis C Virus) Antibody

丙型肝炎抗体

JL-FA-72

HCV Core Antigen Positive

丙肝核心抗原 阳性

JL-FA-73

HCV RNA PLASMA Genotype 1

基因1型丙肝RNA 血浆

JL-FA-74

HCV RNA PLASMA Genotype 2

基因2型丙肝RNA 血浆

JL-FA-75

HCV RNA PLASMA Genotype 3

基因3型丙肝RNA 血浆

JL-FA-76

HCV RNA PLASMA Genotype 4

基因4型丙肝RNA 血浆

JL-FA-77

HCV RNA PLASMA Genotype 5

基因5型丙肝RNA 血浆

JL-FA-78

HCV RNA PLASMA Genotype 6

基因6型丙肝RNA 血浆

JL-FA-79

HCV Riba single band

丙肝免疫印迹单波段

JL-FA-80

HCV RIBA Pos. (multiple bands)

丙肝免疫印迹阳性多波段

JL-FA-81

HCV Negative

丙肝阴性

JL-FA-82

HCV RNA Pos (quantitative)

丙肝RNA阳性(定量)

JL-FA-83

Hepatitis E

戊型肝炎

JL-FA-84

Herpes Simplex Virus (HSV)1/2 Positive Plasma

单纯性疱疹病毒1/2阳性血浆

JL-FA-85

Herpes Simplex Virus (HSV) 1 Negative Plasma

单纯性疱疹病毒1 阴性血浆

JL-FA-86

Herpes Simplex Virus (HSV) 1 IgG

单纯性疱疹病毒1 IGG

JL-FA-87

Herpes Simplex Virus (HSV 1) IgM

单纯性疱疹病毒1 IGM

JL-FA-88

Herpes Simplex Virus (HSV) 2 IgG

单纯性疱疹病毒2 IGG

JL-FA-89

Herpes Simplex Virus (HSV) 2 IgM

单纯性疱疹病毒2 IGG

JL-FA-90

Histone

组蛋白

JL-FA-91

Human Anti Mouse Ab (HAMA)

人抗鼠抗体

JL-FA-92

Human immunodeficiency virus (HIV) 1 Neg

HIV  I 阴性

JL-FA-93

anti Human immunodeficiency virus (HIV) 1 Plasma

抗HIV  I 血浆

JL-FA-94

anti Human immunodeficiency virus (HIV) 1 Serum

抗HIV  I 血清

JL-FA-95

anti Human immunodeficiency virus (HIV) 2 Western Blot Tested

抗HIV  2 免疫印迹

JL-FA-96

anti Human immunodeficiency virus (HIV) 1/2 2 HIV (+)

抗HIV 1/2 2  HIV阳性

JL-FA-97

Human immunodeficiency virus (HIV) Ag

HIV抗原

JL-FA-98

HIV RNA (quantitative) Plasma

HIV RNA 定量血浆

JL-FA-99

HIV RNA (quantitative) Serum

HIV RNA 定量血清

JL-FA-100

HIV1 Subtype A

HIV1  亚型A

JL-FA-101

HIV1 Subtype B

HIV1  亚型B

JL-FA-102

HIV1 Subtype C

HIV1  亚型C

JL-FA-103

HIV1 Subtype D

HIV1  亚型D

JL-FA-104

HIV1 Subtype E

HIV1  亚型E

JL-FA-105

HIV1 Subtype F

HIV1  亚型F

JL-FA-106

HIV1 Subtype G

HIV1  亚型G

JL-FA-107

HIV1 Subtype H

HIV1  亚型H

JL-FA-108

HIV1 Subtype J

HIV1  亚型J

JL-FA-109

HIV1 Subtype K

HIV1  亚型K

JL-FA-110

HIV1 Group O

HIV1  亚型O

JL-FA-111

Human immunodeficiency virus (HIV) 2 Antibody Plasma

HIV 2 抗体血浆

JL-FA-112

Human immunodeficiency virus (HIV) 2 Antibody Serum

HIV 2 抗体血清

JL-FA-113

HPV (Human Papiloma Virus) Negative

人乳状瘤病毒HPV阴性

JL-FA-114

HPV (Human Papiloma Virus) Positive

人乳状瘤病毒HPV阳性

JL-FA-115

Human immunodeficiency virus (HIV) Antibody HCV Antibody Plasma COINFECTED

HIV 抗体  HCV

JL-FA-116

Human T-cell Lymphotropic Virus (HTLV) I/II

人嗜T淋巴细胞病毒(HTLV) I/II

JL-FA-117

Human T-cell Lymphotropic Virus (HTLV) I

人嗜T淋巴细胞病毒(HTLV) I

JL-FA-118

Human T-cell Lymphotropic Virus (HTLV) II

人嗜T淋巴细胞病毒(HTLV) II

JL-FA-119

Jo-1

多发性肌炎抗原JO-1

JL-FA-120

IgE < 5,000 Ku/L

IgE < 5,000 Ku/L

JL-FA-121

Legionella

军团杆菌属

JL-FA-122

Leptospira

军团杆菌属

JL-FA-123

Lyme Disease

莱姆(氏)病:蜱传播的全身性疾病,常在夏季发生

JL-FA-124

Lyme IgG

莱姆(氏)病 IGG

JL-FA-125

Lyme IgM

莱姆(氏)病 IGM

JL-FA-126

Lyme Disease Neg

莱姆(氏)病 阴性

JL-FA-127

Malaria

疟疾

JL-FA-128

Mononucleosis (infectious)

单核细胞增多症(有传染性的)

JL-FA-129

Mononucleosis Negative

单核细胞增多症阴性

JL-FA-130

Measles Negative

麻疹 阴性

JL-FA-131

Measles IgG

麻疹 IGG

JL-FA-132

Measles IgM

麻疹  IGM

JL-FA-133

Microsomal Anti-thyroid peroxidase antibody (TPO) Positive Plasma Standard Titer (typically 1,000-3,000 IU/mL)

微粒体抗甲状腺过氧化物酶抗体

JL-FA-134

Microsomal Anti-thyroid peroxidase antibody (TPO) Negative Plasma

微粒体抗甲状腺过氧化物酶抗体

JL-FA-135

Anti-mitochondrial antibody (AMA)

抗线粒体抗体

JL-FA-136

Multiple Sclerosis

多发性硬化症

JL-FA-137

Mumps IgG

流行性腮腺炎 IGG

JL-FA-138

Mumps Ab IgM

流行性腮腺炎抗体 IGM

JL-FA-139

Mumps Antibody Negative Plasma

流行性腮腺炎抗体阴性血浆

JL-FA-140

Mumps Antibody Negative Serum

流行性腮腺炎抗体阴性血清

JL-FA-141

Myeloma Plasma

骨髓瘤血浆

JL-FA-142

Myeloma IgA

骨髓瘤IGA

JL-FA-143

Myeloma IgE

骨髓瘤IGE

JL-FA-144

Myeloma IgG

骨髓瘤IGG

JL-FA-145

Myeloma IgM

骨髓瘤IGM

JL-FA-146

Mycoplasma

支原体

JL-FA-147

Mycoplasma Negative

支原体阴性

JL-FA-148

Mycoplasma IgG

支原体IGG

JL-FA-149

Mycoplasma IgM

支原体IGM

JL-FA-150

Mycoplasma PCR

支原体PCR

JL-FA-151

Normal Human Plasma

正常人血浆

JL-FA-152

Normal Human Serum

正常人血清

JL-FA-153

Nuclear Antibody Centromere

核抗体着丝粒

JL-FA-154

Nuclear Antibody, Speckled ANA

核抗体,斑点抗核抗体

JL-FA-155

Nuclear Antibody, Nucleolar ANA

核抗体,核仁抗核抗体

JL-FA-156

Nuclear Antibody, Homogeneous ANA

核抗体,同质抗核抗体

JL-FA-157

Nuclear Antiobody, Speckled. (ANA) Negative

核抗体,斑点。抗核抗体阴性

JL-FA-158

P-ANCA (associated neutrophil cytoplasmic antibodies)

相关的嗜中性粒细胞胞浆抗体

JL-FA-159

Parietal Cell Antibody (PCA)

胃)壁细胞抗体

JL-FA-160

Parvo positive plasma

细小病毒阳性血浆

JL-FA-161

Parvo IgM

细小病毒 IGM

JL-FA-162

Parvo IgG

细小病毒 IGG

JL-FA-163

Parvo Negative Plasma

细小病毒阴性血浆

JL-FA-164

Parvo DNA positive

细小病毒 DNA 阳性

JL-FA-165

Phospholipid Positive Plasma

磷脂阳性血浆

JL-FA-166

Prothrombin

凝血酶原,凝血因子

JL-FA-167

Rheumatoid Factor (RF) <1000 IU/mL

类风湿因子<1000 IU/mL

JL-FA-168

Rheumatoid Factor (RF) 1001-2000 IU/mL

类风湿因子1001-2000 IU/mL

JL-FA-169

Rheumatoid Factor (RF) 2001-4000 IU/mL

类风湿因子 2001-4000 IU/mL

JL-FA-170

Rheumatoid Factor (RF) 4001-5000 IU/mL

类风湿因子 4001-5000 IU/mL

JL-FA-171

Rheumatoid Factor (RF) >5000 IU/mL

类风湿因子>5000 IU/mL

JL-FA-172

Ribonucleoprotein (RNP) Positive

核糖核蛋白阳性

JL-FA-173

Rubella Chimeric

风疹

JL-FA-174

Rubella Negative

风疹阴性

JL-FA-175

Rubella IgG

风疹IGG

JL-FA-176

Rubella IgM

风疹IGM

JL-FA-177

Rubeola Negative Plasma

风疹阴性血浆

JL-FA-178

Rubeola IgG

风疹IGG

JL-FA-179

Scleroderma (Scl-70) Pos

胶原沉着病,硬皮病,硬皮症 阳性

JL-FA-180

Scleroderma (Scl-70) Negative

硬皮病阴性

JL-FA-181

Sickle Cell Fresh Whole Blood

镰刀形红细胞新鲜全血

JL-FA-182

Smith (SM)

抗Smith抗体阳性血清(SLE的特征性抗体)

JL-FA-183

SMITH RNP

抗RNP抗体阳性血清(SLE的特征性抗体)

JL-FA-184

Smooth Muscle (ASMA)

抗平滑肌抗体阳性血清

JL-FA-185

Sjogren syndrome antigen A (SSA) Positive

舍格伦综合征或干燥综合征抗原A 阳性

JL-FA-186

Sjogren syndrome antigen B (SSB) Positive

舍格伦综合征抗原B 阳性

JL-FA-187

Sjogren syndrome antigen B (SSB) Negative

舍格伦综合征抗原B阴性

JL-FA-188

Streptolysin O Ab (ASO)

链球菌溶血素O抗体

JL-FA-189

Syphilis (RPR - Rapid Plasma Reagin) Positive Plasma

梅毒(梅毒-快速血浆反应)阳性血浆

JL-FA-190

Syphilis (RPR - Rapid Plasma Reagin) Negative Plasma

梅毒(梅毒-快速血浆反应)阴性血浆

JL-FA-191

Syphilis/ATA/T. pallidum IgG

梅毒ATA/T,苍白球IGG

JL-FA-192

Syphilis/ATA/T. pallidum IgM

梅毒ATA/T,苍白球IGM

JL-FA-193

Systemic Lupus Erythematosus (SLE) Positive

全身性红斑狼疮阳性

JL-FA-194

Systemic Lupus Erythematosus (SLE) Negative

全身性红斑狼疮阴性

JL-FA-195

TG/TPO Positive (Standard Titer 1,000 - 3000 IU/mL)

甲状腺球蛋白/甲状腺过氧化物酶阳性

JL-FA-196

TG/TPO Negative

甲状腺球蛋白/甲状腺过氧化物酶阴性

JL-FA-197

TTG (Tissue Transglutaminase)

组织转谷氨酰胺酶

JL-FA-198

TTG (Tissue Transglutaminase) IgA

组织转谷氨酰胺酶 IGA

JL-FA-199

ToRCH (Toxo, Rubella, CMV, HSV) Positive

优生优育(弓形虫,风疹,巨细胞,单胞)阳性

JL-FA-200

ToRCH (Toxo, Rubella, CMV, HSV) Negative

优生优育(弓形虫,风疹,巨细胞,单胞)阴性

JL-FA-201

Toxoplasmosis (Toxo)

弓形虫病

JL-FA-202

Toxoplasmosis (Toxo) IgG

弓形虫病IGG

JL-FA-203

Toxoplasmosis (Toxo) IgM

弓形虫病IGM

JL-FA-204

Thyroglobulin (TG) Positive Plasma

甲状腺球蛋白阳性血浆

JL-FA-205

Thyroglobulin (TG) Negative

甲状腺球蛋白阴性

JL-FA-206

Varicella-Zoster Virus (VZV) Negative

水痘-带状疱疹病毒阴性

JL-FA-207

Varicella-Zoster Virus (VZV) IgG

水痘-带状疱疹病毒IGG

JL-FA-208

Varicella-Zoster Virus (VZV) IgM

水痘-带状疱疹病毒IGM

JL-FA-209

West Nile Virus (WNV)

西尼罗河脑炎病毒

JL-FA-210

West Nile Virus (WNV) IgM

西尼罗河脑炎病毒IGM

美国Seracare

此次研究中,研究人员通过导入这个基因的拷贝,实现了该受体的过量表达。而实际生活中,并不能将这一做法应用到人身上,因而,研究人员将进一步开发靶向这一基因的药物。
一项来自美国俄亥俄州立大学综合癌症中心的证据显示,经基因修饰的免疫细胞或对多发性骨髓瘤的治疗有效果,且这些细胞可在实验室中培养增殖。该研究成果5月28日刊载在Clinical Cancer  Research杂志。
研究人员对人类免疫细胞(来自患者的细胞系和骨髓瘤细胞)——T淋巴细胞进行修饰,靶向存在于大多数(占比95%以上)的骨髓瘤细胞中的CS1分子,以期杀死细胞。研究人员在实验室中培养增殖这些修饰细胞,然后将其注入动物模型中,杀死人骨髓瘤细胞。
与对照组t细胞相比,修饰T细胞可以更好地识别过表达CS1的多发性骨髓瘤细胞,并激活。注射修饰T细胞的所有小鼠在接受治疗后存活了44天,而在另外两个对照组中,这一数据只有29%和17%。
这种疗法的一个重要的优势是,这些治疗T细胞在体内有复制潜能,所以或许可以抑制肿瘤生长,长时间内避免复发。
墨尔本的研究人员证明,A型白血病能成功地‘逆转’通过诱骗癌症细胞回到正常发育状态。这一发现使用B-前体急性淋巴细胞白血病(B-ALL)模型,是一种zui常见的影响儿童的癌症。研究人员揭示关闭一个称为Pax5的基因在B-ALL模型中能够诱发癌症,而恢复它的功能能够‘治愈’这种疾病。研究发表在《Genes & Development》期刊上。
研究者之一的刘女士说团队利用一种发展的‘基因开关’技术去抑制然后再活化Pax5在白血病模型中。
“随着其它基因变化一起,失活的Pax5驱动正常血细胞变成白血病细胞,之前已经报道过,”刘女士说。“然而我们*揭示重新复活Pax5能够使细胞重新开始其正常发育并丢失那些类似癌症的特性,有效地治疗白血病。吸引我们的是只是回复Pax5就足够使这些癌细胞恢复常态化,尽管其它基因是改变的。”
白血病中,未成熟白血细胞复制异常并在骨髓中累积,干扰正常血细胞的产生。
刘女士说在儿童B-ALL中Pax5常常是一个‘消失’的基因。“Pax5对于一种白血细胞——b细胞正常发育*的,”她说。“当Pax5功能缺乏抵抗力时,发育中的B细胞陷入一种不成熟状态并且变成癌性的。我们证明恢复Pax5功能,即使是在已经发生癌病的细胞中,移除这个‘阻塞’,使得细胞发育成正常白血细胞。”
Dickins博士说这项研究揭示了Pax5的功能,是约100种已知‘抑制’人类肿瘤的基因之一。“当这些肿瘤抑制基因通过改变DNA而被失活时,肿瘤开始发育,”Dickins博士说。

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In this study, researchers introduced an overexpression of this gene by introducing a copy of this gene. And in real life, this practice can not be applied to people, so the researchers will further develop drugs that target this gene.
Evidence from the Ohio State University Comprehensive Cancer Center shows that genetically modified immune cells or treatments for multiple myeloma can be effective and that these cells can be cultured and proliferated in the laboratory. The research was published May 28 in Clinical Cancer Research.
Researchers have modified human immune cells (cell lines from patients and myeloma cells), T-lymphocytes, to target CS1 molecules present in the majority (over 95%) of myeloma cells in order to kill cell. The researchers cultured and cultured these modified cells in a laboratory and injected them into animal models to kill human myeloma cells.
Modification of T cells allows better identification and activation of CS1-overexpressing multiple myeloma cells as compared to control t-cells. All mice injected with modified T cells survived for 44 days after treatment, compared with only 29% and 17% of the other two controls.
An important advantage of this therapies is that these therapeutic T cells have the potential to replicate in the body and so may be able to inhibit tumor growth and avoid relapse for long periods of time.
Researchers in Melbourne have demonstrated that type A leukemia can successfully 'reverse' by inducing cancer cells to return to their normal developmental state. This finding, using the B-ALL acute lymphoblastic leukemia (B-ALL) model, is one of the most common cancers in children. Researchers have revealed that the closure of a gene called Pax5 is capable of inducing cancer in the B-ALL model, and restoring its function to 'cure' the disease. Research published in "Genes & Development" journal.
Ms. Liu, one of the researchers, said the team took advantage of a newly developed 'gene switch' technique to repress and then reactivate Pax5 in leukemia models.
"As other genetic changes, inactivated Pax5 drives normal blood cells to become leukemic cells, as previously reported," Ms. Liu said. "However, for the first time, we have shown that resuscitation of Pax5 allows cells to restart their normal development and lose those cancers-like properties that effectively treat leukemias, and it is enough to appeal to Pax5 that these cells are restored to normalization, although other genes are changed."
In leukemia, immature white blood cells replicate abnormally and accumulate in the bone marrow, interfering with the production of normal blood cells.
Ms. Liu said Pax5 is often a 'vanishing' gene in children with B-ALL. "Pax5 is essential for the normal development of a white blood cell-b cell," she said. "When Pax5 function lacks resistance, developing B cells plunge into an immature state and become cancerous.We show that restoring Pax5 function, even in cells where cancer has already occurred, removes this 'obstruction' , Making the cells develop into normal white blood cells. "
Dr. Dickins said the study revealed the function of Pax5 and is one of about 100 genes known to 'suppress' human tumors. "Tumors begin to develop when these tumor suppressor genes are inactivated by changing DNA," says Dr. Dickins.

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