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Seracare心肌磷脂IgM(Cardiolipin IgM)

Seracare心肌磷脂IgM(Cardiolipin IgM)

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美国SeracareSeracare心肌磷脂IgM(Cardiolipin IgM) 阳性质控品对照品 需要了解更多Seracare产品可以咨询我们,本产品由广州健仑生物科技有限公司提供

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美国Seracare心肌磷脂IgM(Cardiolipin IgM)

广州健仑生物科技有限公司

广州健仑长期供应各种生物原料,主要代理品牌:美国Seracare、西班牙Certest、美国Fuller等等。

主要产品包括各种标准品、阳性对照品、单克隆抗原抗体。

其中常见的有:弓形虫病、西尼罗河病毒、类风湿因子、疟疾、麻疹、莱姆病、百日咳杆菌、大肠杆菌、鼠伤寒沙门氏菌、李斯特菌等阳性对照品。

美国Seracare心肌磷脂IgM(Cardiolipin IgM)

我司还提供其它进口或国产试剂盒:登革热、疟疾、流感、A链球菌、合胞病毒、腮病毒、乙脑、寨卡、黄热病、基孔肯雅热、克锥虫病、违禁品滥用、肺炎球菌、军团菌、化妆品检测、食品安全检测等试剂盒以及日本生研细菌分型诊断血清、德国SiFin诊断血清、丹麦SSI诊断血清等产品。

欢迎咨询

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【Seracare产品介绍】

编号

英文名称

中文名称

JL-FA-01

Amebiasis (AME)

阿米巴病

JL-FA-02

Allergens, Rast scores

过敏原,放射性过敏原吸收实验。指对特定的人群引起免疫反应或者过敏反应的食品中的蛋白质

JL-FA-03

Allergens, Rast scores negative

过敏原,放射性过敏原吸收实验阴性

JL-FA-04

Anti-cyclic citrullinated peptide Antibody (CCP) Arthritis

抗环瓜氨酸肽抗体

JL-FA-05

ASCA Saccharomyces Cerevi

人抗酿酒酵母抗体(ASCA)

JL-FA-06

Aspergillis

麴菌病

JL-FA-07

Beta 2 Glycoprotein

β2糖蛋白

JL-FA-08

Beta 2 Glycoprotein  IgM

β2糖蛋白 IGM

JL-FA-09

Bordela Pertussis

百日咳杆菌

JL-FA-10

Bordela Pertussis IgM

百日咳杆菌 IGM

JL-FA-11

C-ANCA

C-抗中性粒细胞胞浆抗体(ANCA)

JL-FA-12

Cardiolipin

心肌磷脂

JL-FA-13

Cardiolipin IgA

心肌磷脂 IGA

JL-FA-14

Cardiolipin IgG

心肌磷脂 IGG

JL-FA-15

Cardiolipin IgM

心肌磷脂 IGM

JL-FA-16

Cerebral Spinal Fluid

脑脊髓液

JL-FA-17

Chagas

恰加斯病/南美锥虫

JL-FA-18

Chlamydia

衣原体

JL-FA-19

Chlamydia IgA

衣原体IGA

JL-FA-20

Chlamydia IgG

衣原体IGG

JL-FA-21

Chlamydia IgM

衣原体IGM

JL-FA-22

Chlamydia Neg

衣原体阴性

JL-FA-23

Clotting Factor C3

凝固因子C3

JL-FA-24

Clotting Factor C4

凝固因子C4

JL-FA-25

Coccidiodes

球孢菌

JL-FA-26

Cytomegalovirus (CMV) Neg

巨细胞病毒抗体阴性

JL-FA-27

CMV IgG

巨细胞病毒 IGG阳性

JL-FA-28

CMV IgM VCA

巨细胞病毒 IGM 阳性

JL-FA-29

C-Reactive Protein (CRP)

C-反应蛋白质

JL-FA-30

Dengue Fever

登革热

JL-FA-31

Dengue Fever IgM

登革热 IGM

JL-FA-32

DS (Double Stranded) DNA

双链脱氧核糖核酸

JL-FA-33

EBNA (Epstein-Barr nuclear antigen) IgG

EB病毒核抗原 IGG

JL-FA-34

EBNA (Epstein-Barr nuclear antigen) IgM

EB病毒核抗原 IGM

JL-FA-35

Epstein Barr Virus (EBV) Negative Plasma

EB病毒阴性血浆

JL-FA-36

Epstein Barr Virus (EBV) EA IgM

EB病毒早期抗原 IGM

JL-FA-37

Epstein Barr Virus (EBV) VCA IgM

EB病毒壳蛋白  IGM

JL-FA-38

Epstein Barr Virus (EBV) EA IgG

EB病毒早期抗原 IGG

JL-FA-39

EMA (Endomysial Antibodies)

肌内膜

JL-FA-40

Gliadin

麸蛋白,麦醇溶蛋白,麦胶蛋白

JL-FA-41

Gliadin IgG

麦醇溶蛋白  IGG

JL-FA-42

Gliadin IgA

麦醇溶蛋白 IGA

JL-FA-43

Glomerular Basement Membrane (GBMA)

肾小球基底膜病

JL-FA-44

Helicobacter pylori IgA

幽门螺旋杆菌IGA

JL-FA-45

Helicobacter pylori IgG

幽门螺旋杆菌IGG

JL-FA-46

Helicobacter pylori IgM

幽门螺旋杆菌IGM

JL-FA-47

Helicobacter pylori Negative

幽门螺旋杆菌阴性

JL-FA-48

Helicobacter pylori Positive Plasma

幽门螺旋杆菌阴性血浆

JL-FA-49

Hepatitis A Virus (HAV) Pos. Plasma

甲型肝炎病毒阳性血浆

JL-FA-50

Hepatitis A Virus (HAV) IgM

甲型肝炎病毒IGM

JL-FA-51

Hepatitis B Core (HBc) IgG

乙型肝炎病毒核心 IGG

JL-FA-52

Hepatitis B Core (HBc) IgM

乙型肝炎病毒核心 IGM

JL-FA-53

Anti Hbe (Antibody to HBV antigen)

乙肝抗体

JL-FA-54

Hepatitis Delta Virus

丁型肝炎病毒

JL-FA-55

HBeAg (HBV e antigen)

乙肝 E抗原

JL-FA-56

anti-HBs (HBV surface antibody)

乙肝表面抗体

JL-FA-57

Hepatitis B (HBsAg) "Chronic"

乙型肝炎(乙肝表面抗原)“慢性病

JL-FA-58

HBsAg (HBV surface antigen) Serum

乙肝表面抗原血清

JL-FA-59

HBsAg (AD)

乙肝表面抗原(AD)

JL-FA-60

HBsAg (AY)

乙肝表面抗原(AY)

JL-FA-61

HBV Positive Plasma

乙肝阳性血浆

JL-FA-62

HBV DNA Plasma

乙肝DNA血浆

JL-FA-63

HBV DNA Serum

乙肝DNA血清

JL-FA-64

HBV DNA type A

 A型 乙肝DNA

JL-FA-65

HBV DNA type B

 B型 乙肝DNA

JL-FA-66

HBV DNA type C

 C型 乙肝DNA

JL-FA-67

HBV DNA type D

 D型 乙肝DNA

JL-FA-68

HBV DNA type E

 E型 乙肝DNA

JL-FA-69

HBV DNA type F

 F型 乙肝DNA

JL-FA-70

HBV Antibody HCV Antibody Plasma CO-INFECTED

乙肝和丙肝联合感染血浆

JL-FA-71

HCV (Hepatitis C Virus) Antibody

丙型肝炎抗体

JL-FA-72

HCV Core Antigen Positive

丙肝核心抗原 阳性

JL-FA-73

HCV RNA PLASMA Genotype 1

基因1型丙肝RNA 血浆

JL-FA-74

HCV RNA PLASMA Genotype 2

基因2型丙肝RNA 血浆

JL-FA-75

HCV RNA PLASMA Genotype 3

基因3型丙肝RNA 血浆

JL-FA-76

HCV RNA PLASMA Genotype 4

基因4型丙肝RNA 血浆

JL-FA-77

HCV RNA PLASMA Genotype 5

基因5型丙肝RNA 血浆

JL-FA-78

HCV RNA PLASMA Genotype 6

基因6型丙肝RNA 血浆

JL-FA-79

HCV Riba single band

丙肝免疫印迹单波段

JL-FA-80

HCV RIBA Pos. (multiple bands)

丙肝免疫印迹阳性多波段

JL-FA-81

HCV Negative

丙肝阴性

JL-FA-82

HCV RNA Pos (quantitative)

丙肝RNA阳性(定量)

JL-FA-83

Hepatitis E

戊型肝炎

JL-FA-84

Herpes Simplex Virus (HSV)1/2 Positive Plasma

单纯性疱疹病毒1/2阳性血浆

JL-FA-85

Herpes Simplex Virus (HSV) 1 Negative Plasma

单纯性疱疹病毒1 阴性血浆

JL-FA-86

Herpes Simplex Virus (HSV) 1 IgG

单纯性疱疹病毒1 IGG

JL-FA-87

Herpes Simplex Virus (HSV 1) IgM

单纯性疱疹病毒1 IGM

JL-FA-88

Herpes Simplex Virus (HSV) 2 IgG

单纯性疱疹病毒2 IGG

JL-FA-89

Herpes Simplex Virus (HSV) 2 IgM

单纯性疱疹病毒2 IGG

JL-FA-90

Histone

组蛋白

JL-FA-91

Human Anti Mouse Ab (HAMA)

人抗鼠抗体

JL-FA-92

Human immunodeficiency virus (HIV) 1 Neg

HIV  I 阴性

JL-FA-93

anti Human immunodeficiency virus (HIV) 1 Plasma

抗HIV  I 血浆

JL-FA-94

anti Human immunodeficiency virus (HIV) 1 Serum

抗HIV  I 血清

JL-FA-95

anti Human immunodeficiency virus (HIV) 2 Western Blot Tested

抗HIV  2 免疫印迹

JL-FA-96

anti Human immunodeficiency virus (HIV) 1/2 2 HIV (+)

抗HIV 1/2 2  HIV阳性

JL-FA-97

Human immunodeficiency virus (HIV) Ag

HIV抗原

JL-FA-98

HIV RNA (quantitative) Plasma

HIV RNA 定量血浆

JL-FA-99

HIV RNA (quantitative) Serum

HIV RNA 定量血清

JL-FA-100

HIV1 Subtype A

HIV1  亚型A

JL-FA-101

HIV1 Subtype B

HIV1  亚型B

JL-FA-102

HIV1 Subtype C

HIV1  亚型C

JL-FA-103

HIV1 Subtype D

HIV1  亚型D

JL-FA-104

HIV1 Subtype E

HIV1  亚型E

JL-FA-105

HIV1 Subtype F

HIV1  亚型F

JL-FA-106

HIV1 Subtype G

HIV1  亚型G

JL-FA-107

HIV1 Subtype H

HIV1  亚型H

JL-FA-108

HIV1 Subtype J

HIV1  亚型J

JL-FA-109

HIV1 Subtype K

HIV1  亚型K

JL-FA-110

HIV1 Group O

HIV1  亚型O

JL-FA-111

Human immunodeficiency virus (HIV) 2 Antibody Plasma

HIV 2 抗体血浆

JL-FA-112

Human immunodeficiency virus (HIV) 2 Antibody Serum

HIV 2 抗体血清

JL-FA-113

HPV (Human Papiloma Virus) Negative

人乳状瘤病毒HPV阴性

JL-FA-114

HPV (Human Papiloma Virus) Positive

人乳状瘤病毒HPV阳性

JL-FA-115

Human immunodeficiency virus (HIV) Antibody HCV Antibody Plasma COINFECTED

HIV 抗体  HCV

JL-FA-116

Human T-cell Lymphotropic Virus (HTLV) I/II

人嗜T淋巴细胞病毒(HTLV) I/II

JL-FA-117

Human T-cell Lymphotropic Virus (HTLV) I

人嗜T淋巴细胞病毒(HTLV) I

JL-FA-118

Human T-cell Lymphotropic Virus (HTLV) II

人嗜T淋巴细胞病毒(HTLV) II

JL-FA-119

Jo-1

多发性肌炎抗原JO-1

JL-FA-120

IgE < 5,000 Ku/L

IgE < 5,000 Ku/L

JL-FA-121

Legionella

军团杆菌属

JL-FA-122

Leptospira

军团杆菌属

JL-FA-123

Lyme Disease

莱姆(氏)病:蜱传播的全身性疾病,常在夏季发生

JL-FA-124

Lyme IgG

莱姆(氏)病 IGG

JL-FA-125

Lyme IgM

莱姆(氏)病 IGM

JL-FA-126

Lyme Disease Neg

莱姆(氏)病 阴性

JL-FA-127

Malaria

疟疾

JL-FA-128

Mononucleosis (infectious)

单核细胞增多症(有传染性的)

JL-FA-129

Mononucleosis Negative

单核细胞增多症阴性

JL-FA-130

Measles Negative

麻疹 阴性

JL-FA-131

Measles IgG

麻疹 IGG

JL-FA-132

Measles IgM

麻疹  IGM

JL-FA-133

Microsomal Anti-thyroid peroxidase antibody (TPO) Positive Plasma Standard Titer (typically 1,000-3,000 IU/mL)

微粒体抗甲状腺过氧化物酶抗体

JL-FA-134

Microsomal Anti-thyroid peroxidase antibody (TPO) Negative Plasma

微粒体抗甲状腺过氧化物酶抗体

JL-FA-135

Anti-mitochondrial antibody (AMA)

抗线粒体抗体

JL-FA-136

Multiple Sclerosis

多发性硬化症

JL-FA-137

Mumps IgG

流行性腮腺炎 IGG

JL-FA-138

Mumps Ab IgM

流行性腮腺炎抗体 IGM

JL-FA-139

Mumps Antibody Negative Plasma

流行性腮腺炎抗体阴性血浆

JL-FA-140

Mumps Antibody Negative Serum

流行性腮腺炎抗体阴性血清

JL-FA-141

Myeloma Plasma

骨髓瘤血浆

JL-FA-142

Myeloma IgA

骨髓瘤IGA

JL-FA-143

Myeloma IgE

骨髓瘤IGE

JL-FA-144

Myeloma IgG

骨髓瘤IGG

JL-FA-145

Myeloma IgM

骨髓瘤IGM

JL-FA-146

Mycoplasma

支原体

JL-FA-147

Mycoplasma Negative

支原体阴性

JL-FA-148

Mycoplasma IgG

支原体IGG

JL-FA-149

Mycoplasma IgM

支原体IGM

JL-FA-150

Mycoplasma PCR

支原体PCR

JL-FA-151

Normal Human Plasma

正常人血浆

JL-FA-152

Normal Human Serum

正常人血清

JL-FA-153

Nuclear Antibody Centromere

核抗体着丝粒

JL-FA-154

Nuclear Antibody, Speckled ANA

核抗体,斑点抗核抗体

JL-FA-155

Nuclear Antibody, Nucleolar ANA

核抗体,核仁抗核抗体

JL-FA-156

Nuclear Antibody, Homogeneous ANA

核抗体,同质抗核抗体

JL-FA-157

Nuclear Antiobody, Speckled. (ANA) Negative

核抗体,斑点。抗核抗体阴性

JL-FA-158

P-ANCA (associated neutrophil cytoplasmic antibodies)

相关的嗜中性粒细胞胞浆抗体

JL-FA-159

Parietal Cell Antibody (PCA)

胃)壁细胞抗体

JL-FA-160

Parvo positive plasma

细小病毒阳性血浆

JL-FA-161

Parvo IgM

细小病毒 IGM

JL-FA-162

Parvo IgG

细小病毒 IGG

JL-FA-163

Parvo Negative Plasma

细小病毒阴性血浆

JL-FA-164

Parvo DNA positive

细小病毒 DNA 阳性

JL-FA-165

Phospholipid Positive Plasma

磷脂阳性血浆

JL-FA-166

Prothrombin

凝血酶原,凝血因子

JL-FA-167

Rheumatoid Factor (RF) <1000 IU/mL

类风湿因子<1000 IU/mL

JL-FA-168

Rheumatoid Factor (RF) 1001-2000 IU/mL

类风湿因子1001-2000 IU/mL

JL-FA-169

Rheumatoid Factor (RF) 2001-4000 IU/mL

类风湿因子 2001-4000 IU/mL

JL-FA-170

Rheumatoid Factor (RF) 4001-5000 IU/mL

类风湿因子 4001-5000 IU/mL

JL-FA-171

Rheumatoid Factor (RF) >5000 IU/mL

类风湿因子>5000 IU/mL

JL-FA-172

Ribonucleoprotein (RNP) Positive

核糖核蛋白阳性

JL-FA-173

Rubella Chimeric

风疹

JL-FA-174

Rubella Negative

风疹阴性

JL-FA-175

Rubella IgG

风疹IGG

JL-FA-176

Rubella IgM

风疹IGM

JL-FA-177

Rubeola Negative Plasma

风疹阴性血浆

JL-FA-178

Rubeola IgG

风疹IGG

JL-FA-179

Scleroderma (Scl-70) Pos

胶原沉着病,硬皮病,硬皮症 阳性

JL-FA-180

Scleroderma (Scl-70) Negative

硬皮病阴性

JL-FA-181

Sickle Cell Fresh Whole Blood

镰刀形红细胞新鲜全血

JL-FA-182

Smith (SM)

抗Smith抗体阳性血清(SLE的特征性抗体)

JL-FA-183

SMITH RNP

抗RNP抗体阳性血清(SLE的特征性抗体)

JL-FA-184

Smooth Muscle (ASMA)

抗平滑肌抗体阳性血清

JL-FA-185

Sjogren syndrome antigen A (SSA) Positive

舍格伦综合征或干燥综合征抗原A 阳性

JL-FA-186

Sjogren syndrome antigen B (SSB) Positive

舍格伦综合征抗原B 阳性

JL-FA-187

Sjogren syndrome antigen B (SSB) Negative

舍格伦综合征抗原B阴性

JL-FA-188

Streptolysin O Ab (ASO)

链球菌溶血素O抗体

JL-FA-189

Syphilis (RPR - Rapid Plasma Reagin) Positive Plasma

梅毒(梅毒-快速血浆反应)阳性血浆

JL-FA-190

Syphilis (RPR - Rapid Plasma Reagin) Negative Plasma

梅毒(梅毒-快速血浆反应)阴性血浆

JL-FA-191

Syphilis/ATA/T. pallidum IgG

梅毒ATA/T,苍白球IGG

JL-FA-192

Syphilis/ATA/T. pallidum IgM

梅毒ATA/T,苍白球IGM

JL-FA-193

Systemic Lupus Erythematosus (SLE) Positive

全身性红斑狼疮阳性

JL-FA-194

Systemic Lupus Erythematosus (SLE) Negative

全身性红斑狼疮阴性

JL-FA-195

TG/TPO Positive (Standard Titer 1,000 - 3000 IU/mL)

甲状腺球蛋白/甲状腺过氧化物酶阳性

JL-FA-196

TG/TPO Negative

甲状腺球蛋白/甲状腺过氧化物酶阴性

JL-FA-197

TTG (Tissue Transglutaminase)

组织转谷氨酰胺酶

JL-FA-198

TTG (Tissue Transglutaminase) IgA

组织转谷氨酰胺酶 IGA

JL-FA-199

ToRCH (Toxo, Rubella, CMV, HSV) Positive

优生优育(弓形虫,风疹,巨细胞,单胞)阳性

JL-FA-200

ToRCH (Toxo, Rubella, CMV, HSV) Negative

优生优育(弓形虫,风疹,巨细胞,单胞)阴性

JL-FA-201

Toxoplasmosis (Toxo)

弓形虫病

JL-FA-202

Toxoplasmosis (Toxo) IgG

弓形虫病IGG

JL-FA-203

Toxoplasmosis (Toxo) IgM

弓形虫病IGM

JL-FA-204

Thyroglobulin (TG) Positive Plasma

甲状腺球蛋白阳性血浆

JL-FA-205

Thyroglobulin (TG) Negative

甲状腺球蛋白阴性

JL-FA-206

Varicella-Zoster Virus (VZV) Negative

水痘-带状疱疹病毒阴性

JL-FA-207

Varicella-Zoster Virus (VZV) IgG

水痘-带状疱疹病毒IGG

JL-FA-208

Varicella-Zoster Virus (VZV) IgM

水痘-带状疱疹病毒IGM

JL-FA-209

West Nile Virus (WNV)

西尼罗河脑炎病毒

JL-FA-210

West Nile Virus (WNV) IgM

西尼罗河脑炎病毒IGM

美国

RTKs通过光激活二聚化作用调节发育是哺乳动物受体的光激活二聚化作用的*个实例。光控制下的RTK提供了强大的光遗传学的方法来启动细胞信号和操纵细胞的行为。新开发的受体引发癌症和血液中内皮细胞复杂的细胞活动。这些细胞代表根据光控行为的新模型,以及能够用新的方法来确定药物。这与癌细胞的相反,细胞信号转导的不受控制的活化导致恶性肿瘤有关的特征,信号转导的光激活可能拯救退行性疾病的细胞存活和功能。
“渐冻症”是运动神经元病的一种,患者逐渐丧失运动机能甚至瘫痪,其中有名的是英国科学家霍金。这种病被认为与神经胶质细胞异常有关,神经胶质细胞可负责维持神经细胞的网络并向神经细胞提供营养。
京都大学教授井上治久率领的研究小组,利用ips细胞制作出可变化为神经胶质细胞的前驱细胞,然后向24只患有渐冻症的实验鼠脊髓各移植了约8万个这种细胞。
结果发现,移植了前驱细胞的24只渐冻症实验鼠的平均生存期为162天,而没有移植的24只实验鼠仅为150天。研究小组说,移植的前驱细胞几乎全部变为神经胶质细胞之一的星形胶质细胞,开始产生维持神经细胞所需的蛋白质,而且这些移植的细胞没有发生癌变。
研究小组还说,实验鼠的10天相当于人类的数个月到半年时间,不过单纯换算为天数比较困难。他们准备今后将这种前驱细胞与利用iPS细胞制作的运动神经细胞一起移植,以调查会取得什么样的效果。
英国布里斯托尔大学,得克萨斯大学西南医学中心和梅奥诊所的研究人员发现,一个基因的突变,削弱了细胞内的正常转运蛋白的能力。
这些蛋白质的缺乏可能是为什么身体会失去负责产生化学物质多巴胺的神经细胞的部分原因。
已知VPS35基因突变与帕金森氏病有关,但直到现在,专家一直无法查明其作用机制。
发表于2014年6月26日的《Current biology》杂志上的这项研究表明,VPS35突变削弱细胞转运货物蛋白质的一个子集到正确目的地的能力。
他们还确定了影响这个突变的三个额外蛋白质,其中的一些与帕金森氏病有关。
布里斯托尔大学的生物化学教授彼得·卡伦说:“与VPS35突变相关的分子缺陷的发现,为研究这种疾病的病因提供了一个令人兴奋的潜在途径。本研究显著提供越来越多的证据表明,VPS35是retromer复合体中的一部分,是帕金森氏病和其他神经退行性疾病的一个潜在治疗靶点。”

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【公司名称】 广州健仑生物科技有限公司
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RTKs regulate development through photoactivation dimerization as the first instance of photoreactive dimerization of mammalian receptors. RTK under light control provides a powerful method of optogenetics to initiate cellular signaling and manipulate cellular behavior. The newly developed receptors trigger complex cellular activities of cancer and endothelial cells in the blood. These cells represent new models based on photocontrol behavior, as well as being able to identify new drugs in new ways. This is in contrast to cancer cells, where uncontrolled activation of cell signaling leads to malignancy-related features, and photo-activation of signal transduction may rescue the cell survival and function of degenerative diseases.
"Asymptomatic" is a kind of motor neuron disease, patients gradually lose motor function or even paralysis, of which the most famous is the British scientist Hawking. The disease is thought to be associated with abnormalities in glial cells, which can be responsible for maintaining the network of nerve cells and providing nutrients to nerve cells.
A team led by Professor Inoue Ishiguro of Kyoto University made ips cells to make precursor cells that could change into glial cells. Then, about 80,000 of these 24 cells were transplanted into the spinal cord of 24 experimental rats with gradual freezing frost.
The results showed that the average survival time of 24 mice with asherogenic syndrome transplanted with precursor cells was 162 days compared to only 150 days with 24 mice without transplantation. The team said almost all of the transplanted precursor cells became astrocytes, one of the glial cells, and started producing the proteins needed to sustain the nerve cells, and none of the transplanted cells were cancerous.
The team also said that 10 days of experimental mice is equivalent to a few months to six months of human life, but simple conversion to days is more difficult. In the future, they plan to transplant such precursor cells together with motor nerve cells made from iPS cells to investigate what effect they can achieve.
Researchers at the University of Bristol, the University of Texas Southwestern Medical Center and Mayo Clinic have found that a mutation in a gene impairs the ability of normal transporters within the cell.
The lack of these proteins may be part of the reason why the body loses nerve cells responsible for the chemical dopamine production.
Known VPS35 gene mutation and Parkinson's disease, but until now, experts have been unable to identify the mechanism of action.
The study, published in Current Biology, June 26, 2014, shows that VPS35 mutations impair the ability of cells to transport a subset of cargo proteins to the correct destination.
They also identified three additional proteins that affect this mutation, some of which are related to Parkinson's disease.
Peter Karen, a professor of biochemistry at the University of Bristol, said: "The discovery of molecular defects associated with mutations in VPS35 provides an exciting and potential pathway for studying the etiology of this disease." This study significantly provided more and more There is much evidence that VPS35 is part of the retromer complex and is a potential therapeutic target for Parkinson's disease and other neurodegenerative diseases. "

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